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​Publications

​*Corresponding author

​2024年

  1. Ushio A, Matsuda-Lennikov M, Kalle-Youngoue F, Shimizu A, Abdelmaksoud A, Kelly MC, Ishimaru N, Takahama Y. Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance. Cell Rep. 2024 43:114072 

  2. ​Tawara H, Tsunematsu T*, Kitajima S, Nagao R, Matsuzawa S, Otsuka K, Ushio A, Ishimaru N. The non-canonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells. Biochem Biophys Res Commun. 2024, 706:149741.

​2023年

  1. Shimizu M, Hojo M, Ikushima K, Yamamoto Y, Maeno A, Sakamoto Y, Ishimaru N, Taquahashi Y, Kanno J, Hirose A, Suzuki J, Inomata A, Nakae D. Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routs during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7. J Toxicol Sci. 2023, 12:617-639.

  2. Jin S, Tsunematsu T, Horiguchi T, Mouri Y, Shao W, Miyoshi K, Hagita H, Sarubo M, Fujiwara N, Qi G, Ishimaru N, Kudo Y. Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma. Cancer Med. 2023, 12(24):22156-22169.

  3. Sugimoto A, Iwata K, Kurogoshi R, Tanaka M, NakashimaY, Yamakawa Y, Oishi A, Yoshizaki K, Fukumoto S, Yamamoto A, Ishimaru N, Iwamoto T. C-terminus of PIEZO1 governs Ca2+ influx and intracellular ERK1/2 signaling pathway in mechanotransduction. Biochem Biophys Res Commun. 2023, 682:39-45.1.

  4. Sato-Fukuba M, Arakaki R, Ushio A, Otsuka K,  Nagao R, Matsuzawa S, Tawara H, Tsunematsu T, Ishimaru N*. CD4+ T-cell-dependent differentiation of CD23+ follicular B cells contributes to the pulmonary pathology in a primary Sjögren’s syndrome mouse model. 2023 14:1217492Front Immunol. 2023, 14:1217492

  5. Narwidina A, Miyazaki A, Iwata K, Kurogoushi R, Sugimoto A, Kudo Y, Kawarabayashi K, Yamakawa Y, Akazawa Y, Kitamura T, Nakagawa H, Yamaguchi-Ueda K, Hasegawa T, Yoshizaki K, Fukumoto S, Yamamoto A, Ishimaru N, Iwasaki T, Iwamoto T. Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression. Biochem Biophys Res Commun. 2023, 650:47-54.

  6. Shao W, Tsunematsu T*, Umeda M,​ Tawara H, Fujiwara N, Mouri Y, Arakaki R, Ishimaru N, Kudo Y*. Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma. Cancer Med. 2023, 12(7):8510-8525.

​2022年

  1. ​Sato M, Arakaki R, Tawara H, Nagao R, Tanaka H, Tamura K, Kawahito Y, Ostuka K, Ushio A, Tsunematsu T, Ishimaru N*. Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjogren's syndrome. Front Med. 2022, 9:1036787.

  2. Nagatomo R, Kaneko H, Kamatsuki S, Ichimura-Shimaizu M, Ishimaru N, Tsuneyama K, Inoue K. Short-chain fatty acid profiling in biological samples from a mouse model of Sjögren’s syndrome based on derivatized LC-MS/MS assay. J Chromat B Analyt Technol Biomed Life Sci​. 2022, 1210, 123432.

  3. Tsunematsu T, Arakaki R, Sato M, Saito M, Otsuka K, Furukawa Y, Taquahashi Y, Kanno J, Ishimaru N*. Exposure to Multi-Wall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis. Am J Pathol. doi.org/10.1016/j.ajpath.2022.07.009.

  4. ​Otsuka K, Sato M, Tsunematsu T, Ishimaru N*. Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s syndrome. Viruses. 2022, 14:1474.

  5. Horii Y, Iniwa T, Onitsuka M, Tsukimoto J, Tanaka Y, Ike H, Fukushi Y, Ando H, Takeuchi Y, Nishioka SI, Tsuji D, Ikuo M, Yamazaki N, Takiguchi Y, Ishimaru N, Ito K. Reversal neuroinflammation in novel GS model mice by single i.civ. administration of CHO-derived rhCTSA precursor protein. Mol Ther Methods Clin Dev. 2022, 25:297-310.

  6. Maruhashi T, Sugiura D, Okazaki IM, Shimizu K, Maeda TK, Ikubo J, Yoshikawa H, Maenaka K, Ishimaru N, Kosako H, Takemoto T, Okazaki T. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Immunity. 2022, 55:912-24.

  7. Sugiura D, Okazaki I, Maeda TK, Maruhashi T, Shimizu K, Arakaki R, Takemoto T, Ishimaru N, Okazaki T. PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nat Immunol. 2022, 23(3):339-410.

  8. Shikama Y, Kurosawa M, Furukawa M, Kudo Y, Ishimaru N, Matsushita K. The priming potential of interferon lambda-1 for antiviral defense in the oral mucosa. Inflammation. 2022, 19:1-14.

​2021年

  1. Iwata K, Kawarabayashi K, Yoshizaki K, Yian T, Saito K, Sugimoto A, Kurogoushi R, Yamada A, Yamamoto A, Kudo Y, Ishimaru N, Fukumoto S, Iwamoto T. von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation. J Cell Physiol. 2021, 235(3):1964-1979.

  2. Chen S, Tamaki N, Kudo Y, Tsunematsu T, Miki K, Ishimaru N, Ito HO. Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes. J Clin Biochem Nutr. 2021, 69(3):238-246.

  3. Shao W, Fujiwara N, Mouri Y, Kisoda S, Yoshida K, Yoshida K, Yumoto H, Ozaki K, Ishimaru N, Kudo Y. Conversion from epithelial to partial-EMT phenotype by Fosobacterium nucleatum infection promotes invasion of oral cancer cells. Sci Rep. 2021, 11(1): 14943.

  4. Yoshikawa Y, Izawa T, Hamada Y, Takenaga H, Wang Z, Ishimaru N, Kamioka H. zrole of B[a]P and FICZ in subchondral bone metabolism and epeperimantal temporomandibular joint osteoarthritis via AhR/Cyp 1a1 signaling axis. Sci Rep. 2021, 11(1): 14927

  5. ​Sato M, Arakaki R, Tawara H, Tsunematsu T, Ishimaru N*. Formation of Autoimmune Lesions is Independent of Antibiotic Treatment in NOD mice. Int J Mol Sci, 2021, 22,3239.

  6. Ohigashi I, Frantzeskakis M, Jacques A, Fujimori S, Ushio A, Yamashita F, Ishimaru N, Yin D, Cam M, Kelly M, Awasthi P, Takada T, Takahama Y. Thymoproteasome hardwires TCR repertoire of CD8+ T cells with cortical positive selection independent of negative selection. J Exp Med. 2021, 218(4):e20201904.

  7. Kurosawa M, Shikama Y, Furukawa M, Arakakai R, Ishimaru N, Matsushita K. Chemokines upregulated in epithelial cells control senescence-associated T cell accumulation in salivary glands of aged and Sjögren’s syndrome model mice. Int J Mol Sci. 2021, 22:2302.

​2020年

  1. Tsunematsu T, Arakaki R, Kawai H, Ruppert J, Yamada A, Tsuneyama K, Ishimaru N, Earnshaw WC, Pagano M, Kudo Y. APC/C-Cdh1 is required for the termination of CPC activity upon mitotic exit. J Cell Sci. 2020, 133(18): jcs251314.

  2. Kisoda S, Shao W, Fujiwara N, Mouri Y, Tsunematsu T, Jin S, Arakaki R, Ishimaru N, Kudo Y. Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis. Oral Dis Apr 11. doi: 10.1111/odi.13351.

  3. ​Tada H, Shao W, Ishimaru N, Kudo Y. The life in Japan and status of private dental office at the times of COVID-19 Oral Dis. 2020, 10.1111/odi.13449.

  4. Chatrath A, Przanowska R, Kiran S, Su Z, Saha S, Wilson B, Tsunematsu T, Ahn J, Lee KY, Paulsen T, Sobierajsa E, Kiran M, Tang X, Li T, Kumar P, Ratan A, Dutta A. The Pan-Cancer Landscape of Prognostic Germline Variants in 10,582 Patients. Genome Med. 2020, 12(1):15.

​2019年

  1. Yuyama K, Nakamura Y, Tateyama R, Arakaki R, Tsutsui T, Ishimaru N. Study of the pharmacokinetics of eriodictyol-6-C-β-d-glucoside, a flavonoid of rooibos (Aspalathus linearis) extract, after its oral administration in mice. J Chromatogor B Analyt Technol Biomed Life Sci. 2019, 1137:121881

  2. Miyazaki A, Sugimoto A, Yoshizaki K, Kawarabayashi K, Iwata K, Kurogoushi R, Kitamura T, Otsuka K, Hasegawa T, Akazawa Y, Fukumoto S, Ishimaru N, Iwamoto T. Coordination of WNT signaling and clliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1. Sci Rep. 2019, 9(1):14762

  3. Shikama Y, Kurosawa M, Furukawa M, Ishimaru N, Matsushita K. Involvement of adiponectin in age-related increases in tear production in mice. Aging. 2019, 11(19):8329-8346

  4. Otsuka K, Yamada A, Saito M, Ushio A, Sato M, Kisoda S, Shao W, Tsunematsu T, Kudo Y, Arakaki R, Ishimaru N*. Ascl2-Regulated Follicular Helper T Cells promote Autoimmunity in a Murine Model for Sjögren’s Syndrome. Am J Pathol. 2019, 9440(19):30712-6

  5. Arakaki R, Ushio A, Kisoda S, Sato M, Nakamura Y, Yuyama K, Tateyama R, Morishita S, Monoi N, Kudo Y, Ishimaru N*. Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice. J Oral Biosci. 2019, 61(3):179-182

  6. Arakaki R, Ushio A, Otsuka K, Kudo Y, Ishimaru N*. A novel method for measuring small amounts of saliva in mice. Oral Sci Int. 2019, 16(3):178-180

  7. Nakatomi C, Nakatomi M, Matsubara T, Komori T, Doi-Inoue T, Ishimaru N, Weih F, Iwamoto T, Matsuda M, Kokabu S, Jimi E. Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification. Bone. 2019, 121:29-41

​2018年

  1. Ushio A, Arakaki R, Otsuka K, Yamada A, Tsunematsu T, Kudo Y, Aota K, Azuma M, Ishimaru N*. CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome. Front Immunol. 2018, 9:2594.

  2. Otsuka K, Yamada K, Taquahashi Y, Arakaki R, Ushio A, Saito M, Yamada A, Tsunematsu T, Kudo Y, Kanno J, Ishimaru N*. Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes. PLoS One. 2018, 13(10):e0205702.

  3. Aota K, Yamanoi T, Kani K, Nakashiro KI, Ishimaru N, Azuma M. Inverse correlation between the number of CXCR3+ macrophages and the severity of inflammatory lesions in Sjogren’s syndrome salivary glands: A pilot study. J Oral Pathol Med. 2018 47(7): 710-718

  4. Siriwardena SBSM, Tsunematsu T, Qi G, Ishimaru N, Kudo Y. Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma- A Review. Int J Mol Sci 2018, 19(5): E1462

  5. Qi G, Liu J, Mi S, Tsunematsu T, Jin S, Shao W, Liu T, Ishimaru N, Tang B, Kudo Y. Aurora kinase inhibitors in head and neck cancer. Curr Top Med Chem. 2018, 18(3): 199-213

  6. Utaijaratrasmi P, Vaeteewoottacharn K, Tsunematsu T, Jamjantra P, Wongkham S, Pairojkul C, Khuntikeo N, Ishimaru N, Sirivatanauksorn Y, Pongpaibul A, Thuwajit C, Kudo Y. The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migrateon of cancer cells. Mol Cancer. 2018 17(1):10

  7. Aota K, Kani, Yamanoi T, Nakashiro K, Ishimaru N, Azuma M. Distinct regulation of CXCL10 production by chemokines in human salivary gland ductal and acinar cells. Inflammation. 2018, 41(4): 1172-1181

​2017年

  1. Tada H, Fujiwara N, Tsunematsu T, Tada Y, Arakaki R, Tamaki N, Ishimaru N, Kudo Y. Preventive effects of mouthguard use while sleeping onrecurrent aphthous stomatitis: Preliminary intervenetional study. Clin Exp Dent Res. 2017 3:198-203

  2. Izawa T, Arakaki R, Ishimaru N. Crosstalk between Cytokine RANKL and AhR Sugnalling in Osteoclasts Controls Bone Homeostasis. J Cytokine Biol. 2017, 2:1-5

  3. Ushio A, Arakaki R, Eguchi H, Hotta F, Yamada A, Kudo Y, Ishimaru N. Pathological analysis of ocular lesions in a murine model of Sjögren’s syndrome. Int J Mol Sci. 2017, 18(6) E1209

  4. Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y. Essential role of CCL21 in establishment of central self-tolerance in T cells. J Exp Med. 2017, 214:1925-1935.

  5. Izawa T, Arakaki R, Ishimaru N. Role of Fas and RANKL signaling in peripheral immune tolerance. J Clin Cell Immunol. 2017, 8(4):1000512

  6. Kurosawa M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Sprent J, Ishimaru N. NF-κB2 controls migratory activity of memory T cells by regulating expression of CXCR4 in a mouse model of Sjögren’s syndrome. Arthritis Rheumatol. 2017, 69(11):2193-2202.

  7. Saito M, Otuska K, Ushio A, Yamada A, Arakakai R, Kudo Y, Ishimaru N. Unique phenotypes and functions of follicular helper T cell and regulatory T cell in Sjögren’s syndrome. Curr Rheumatol Rev. 2017, 14(3):239-245

  8. Shikama Y, Kudo Y, Ishimaru N, Funaki M. Potential role of free fatty acids in the pathogensis of perioditis and primary Sjögren’s syndrome. Int J Mol Sci. 2017, 18:e836

  9. Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Tohyama R, Tanaka M, Kobayashi Y, Kondo T, Ushio A, Otsuka K, Kurosawa M, Saito M. Yamada A, Arakaki R, Nagai H, Nikai H, Takeuchi K, Nagao T, Miyamoto Y, Ishimaru N, Kudo Y. Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene. Oral Oncol. 2017, 69:46-55

  10. Yamada A, Arakaki R, Saito M, Kudo Y, Ishimaru N. Dual role of Fas/FasL-mediated signal in peripheral immune tolerance. Front in Immunol. 2017 8:403

  11. Ushio A, Arakaki R, Yamada A, Saito M, Tsunematsu T, Kudo Y, Ishimaru N. Crucial roles of macrophages in the pathogenesis of autoimmune disease. World J Immunol. 2017, 7:1-8

​2016年

  1. Izawa T, Arakaki R, Mori H, Tsunematsu T, Kudo Y, Tanaka E, Ishimaru N. The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANKL/c-Fos signaling axis. J Immunol. 2016 197(12):4639-4650

  2. Kudo Y, Tada H, Fujiwara N, Tada Y, Tsunematsu T, Miyake Y, Ishimaru N. Oral environment and cancer. Genes Environ. 2016 38:13

  3. Tsunematsu T, Fujiwara N, Yoshida M, Takayama Y, Kujiraoka S, Qi G, Kitagawa M, Kondo T, Yamada A, Arakaki R, Miyauchi M, Ogawa I, Abiko Y, Nikawa H, Murakani S, Takata T, Ishimaru N, Kudo Y. Human odontogenic epithelial cells derived from epithelial rests of Malassez possess stem cell properties. Lab Invest. 2016 96(10):1063-1075

  4. Yamada A, Arakaki R, Tsunematsu T, Kudo Y, Ishimaru N. A role of regulatory T cell in inflammatory bowel disease. World J Gastroenterol. 2016 22(7):2195-2205

  5. Qi G, Kudo Y, Tang B, Liu T, Jin S, Liu J, Zuo X, Mi S, Shao W, Ma X, Tsunematsu T, Ishimaru N, Zeng S, Tatsuka M, Shimamoto F. PARP6 acts as a tumor suppressor via dowregulating Survivin expression in colorectal cancer. Oncotarget. 2016,7(14):18812-24

  6. Sugawara C, Takahashi A, Kawano F, Kudo Y, Ishimaru N, Miyamoto Y. Intraoral ultrasonography of tongue mass lesions. Dentomaxillofac Radiol. 2016, 45(5):20150362

  7. Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular mechanisms of nickel allergy. Int J Mol Sci. 2016 17(2): e202

  8. Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N. Acceleration of tumor growth due to dysfunction in Ma macrophages and enhanced angiogenesis in an animal model of autoimmune disease. Lab Invest. 2016 96(4):468-480

​2015年

  1. Tsunematsu T, Arakaki R, Yamada A, Ishimaru N, Kudo Y. The non-canonical role of Aurora-A in DNA replication. Front in Oncol 2015 96(4):468-480

  2. Yamada A, Ushio A, Arakaki R, Tsunematsu T, Kudo Y, Hayashi Y, Ishimaru N. Impaired Expansion of Regulatory T Cells in A Neonatal Thymectomy-Induced Autoimmune Mouse Model. Am J Pathol 2015 185(11):2886-2897

  3. Yamano T, Nedjic J, Hinteberger M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L. Intrathymic B cell licensing for Aire expression and T cell tolerance induction. Immunity 2015 42(6):1048-61.

  4. Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F. Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling. Obesity 2015 23(7):1460-71.

  5. Shikama Y, Kudo Y, Ishimaru N, Funaki M. Possible involvement of palmitate in pathogensis of periodontitis. J Cell Physiol. 2015, 230:2981-89.

  6. Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto KI, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I, Yamashiro T. Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015 244(3):488-496.

  7. Sugawara C, Takahashi A, Kawano F, Kudoh T, Yamada A, Ishimaru N, Hara K, Miyamamoto Y. Neuroendocrine tumor in the mandible: a case report with imaging and histopathologyic findings. Oral Sug Oral Med Oral Pathol Oral Radiol. 2015, 119(1):e41-48.

  8. Iwasa A, Arakaki R, Honma N, Ushio A, Yamada A, Kondo T, Kurosawa E, Kujiraoka S, Tsunematsu T, Kudo Y, Tanaka E, Yoshimura N, Harada N, Hayashi Y, Ishimaru N. Aromatase controls Sjögren’s syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages. Am J Pathol. 2014, 185(1):151-161

​2014年

  1. Arakaki R, Yamada A, Kudo Y, Hayashi Y, Ishimaru N. Mechanism of activation-induced cell death of T cells and regulation of FasL expression. Crit Rev Immunol. 2014, 34(4):301-14.

  2. Arakaki R, Eguchi H, Yamada A, Kudo Y, Iwasa A, Enkhmaa T, Hotta F, Mitamura-Aizawa S, Mitamura Y, Hayashi Y, Ishimaru N. Anti-inflammatory effects of rebamipide eyedrop administration on ocular lesions in a murine model of primary Sjögren's syndrome. PLoS One. 2014 9(5):e98390.

  3. Ashrin MN, Arakaki R, Yamada A, Kondo T, Kurosawa M, Kudo Y, Watanabe M,Ichikawa T, Hayashi Y, Ishimaru N. A critical role for thymic stromallymphopoietin in nickel-induced allergy in mice. J Immunol. 2014 192(9):4025-31.

  4. Iizuka S, Ishimaru N, Kudo Y. Matrix metalloproteinases: the gene expression signatures of head and neck cancer progression. Cancers (Basel). 2014 6(1):396-415.

  5. Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y. Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur J Immunol. 2014 44(2):561-72.

  6. Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A. The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci. 2014 71(7):1279-88.

  7. Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto KI, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I, Yamashiro T. Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2014, 1002:24231

​2013年

  1. Kawakami E, Kawai N, Kinouchi N, Mori H, Ohsawa Y, Ishimaru N, Sunada Y, Noji S, Tanaka E. Local applications of myostatin-siRNA with atelocollagen increase skeletal muscle mass and recovery of muscle function. PLoS One. 2013, 8(5):e64719.

  2. Tsunematsu T, Takihara Y, Ishimaru N, Pagano M, Takata T, Kudo Y. Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis. Nat Commun. 2013, 4:1885.

  3. Shimizu N, Nakajima NI, Tsunematsu T, Ogawa I, Kawai H, Hirayama R, Fujimori A, Yamada A, Okayasu R, Ishimaru N, Takata T, Kudo Y. Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells. J Biol Chem. 2013, 288(24):17238-52.

  4. Shikama Y, Ishimaru N, Kudo Y, Bando Y, Aki N, Hayashi Y, Funaki M. Effects of free fatty acids on human salivary gland epithelial cells. J Dent Res. 2013, 92(6):540-6.

  5. Yamada A, Arakaki R, Kudo Y, Ishimaru N. Targeting IL-1 in Sjögren's syndrome. Expert Opin Ther Targets. 2013, (4):393-401.

  6. Oura R, Arakaki R, Yamada A, Kudo Y, Tanaka E, Hayashi Y, Ishimaru N. Induction of rapid T cell death and phagocytic activity by Fas-deficient lpr macrophages. J Immunol. 2013 190(2):578-85.

  7. Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N, Takata T. The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1. Br J Cancer. 2013, 109(8):2248-58.

  8. Hatano H, Ogawa I, Shigeishi H, Kudo Y, Ohta K, Higashikawa K, Takechi M, Takata T, Kamata N. Expression of receptor for hyaluronan-mediated motility (RHAMM) in ossifying fibromas. Histol Histopathol. 2013 28(4):473-80.

​2012年

  1. Izawa T, Kondo T, Kurosawa M, Oura R, Matsumoto K, Tanaka E, Yamada A, Arakaki R, Kudo Y, Hayashi Y, Ishimaru N. Fas-independent T-cell apoptosis by dendritic cells controls autoimmune arthritis in MRL/lpr mice. PLoS One. 2012, 7(12):e48798.

  2. Kudo Y, Iizuka S, Yoshida M, Tsunematsu T, Kondo T, Subarnbhesaj A, Deraz EM, Siriwardena SB, Tahara H, Ishimaru N, Ogawa I, Takata T. Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis. J Biol Chem. 2012, 287(46):38716-28.

  3. Sugawara C, Takahashi A, Kubo M, Otsuka H, Ishimaru N, Miyamoto Y, Honda E. Preoperative evaluation of patients with squamous cell carcinoma of the oral cavity: fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography and ultrasonography versus histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 114(4):516-25.

  4. Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena SB, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, Koizumi K, Maeda M, Ishimaru N, Ogawa I, Takata T. Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer. PLoS One. 2012, 7(8):e44488.

  5. Ishimaru N, Yamada A, Nitta T, Arakaki R, Lipp M, Takahama Y, Hayashi Y. CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. Am J Pathol. 2012, 180(1):199-208.

  6. Hatano H, Kudo Y, Ogawa I, Shimasue H, Shigeishi H, Ohta K, Higashikawa K, Takechi M, Takata T, Kamata N. Establishment of mesenchymal cell line derived from human developing odontoma. Oral Dis. 2012, 18(8):756-62.

  7. Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N. Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/2. J Bone Miner Metab. 2012, 30(3):293-303.

  8. DesRochers TM, Shamis Y, Alt-Holland A, Kudo Y, Takata T, Wang G, Jackson-Grusby L, Garlick JA. The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma. Epigenetics.　2012, 7(1):34-46.

  9. Inubushi T, Kawazoe A, Miyauchi M, Kudo Y, Ao M, Ishikado A, Makino T, Takata T. Molecular mechanisms of the inhibitory effects of bovine lactoferrin on lipopolysaccharide-mediated osteoclastogenesis. J Biol Chem. 2012, 287(28):23527-36.

  10. D'Angiolella V, Donato V, Forrester FM, Jeong YT, Pellacani C, Kudo Y, Saraf A, Florens L, Washburn MP, Pagano M. The Cyclin F-Ribonucleotide Reductase M2 axis controls genome integrity and DNA repair. Cell. 2012, 25;149(5):1023-34.

  11. Bucchieri F, Fucarino A, Marino Gammazza A, Pitruzzella A, Marciano V, Paderni C, De Caro V, Siragusa MG, Lo Muzio L, Holgate ST, Davies DE, Farina F, Zummo G, Kudo Y, Giannola IL, Campisi G. Medium-term culture of normal human oral mucosa: a novel three-dimensional model to study the effectiveness of drugs administration. Curr Pharm Des. 2012, 18(34):5421-30.

  12. Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N. Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/2. J Bone Miner Metab. 2012, 30(3):293-303.

​2011年

  1. Watanabe M, Ishimaru N, Ashrin MN, Arakaki R, Yamada A, Ichikawa T, Hayashi Y. A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice. PLoS One. 2011, 6(4):e19017.

  2. Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bösl MR, Holländer GA, Hayashi Y, Malefyt Rde W, Nitta T, Takahama Y. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med. 2011, 208(2):383-94.

  3. Kawakami E, Kinouchi N, Adachi T, Ohsawa Y, Ishimaru N, Ohuchi H, Sunada Y, Hayashi Y, Tanaka E, Noji S. Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice. Dev Growth Differ. 2011 53(1):48-54.

  4. Yamano T, Watanabe S, Hasegawa H, Suzuki T, Abe R, Tahara H, Nitta T, Ishimaru N, Sprent J, Kishimoto H. Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts. Blood. 2011 117(9):2640-8.

  5. Deraz EM, Kudo Y, Yoshida M, Obayashi M, Tsunematsu T, Tani H, Siriwardena SB,Keikhaee MR, Qi G, Iizuka S, Ogawa I, Campisi G, Lo Muzio L, Abiko Y, Kikuchi A, Takata T. MMP-10/stromelysin-2 promotes invasion of head and neck cancer. PLoS One. 2011, 6(10):e25438.

  6. Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi RU, Takata T, Shimamoto A, Ochiya T, Tahara H. miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol. 2011 193(2):409-24.

  7. Kudo Y, Tsunematsu T, Takata T. Oncogenic role of RUNX3 in head and neck cancer. J Cell Biochem. 2011 112(2):387-93.

  8. Nguyen PT, Kudo Y, Yoshida M, Kamata N, Ogawa I, Takata T. N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition. Histol Histopathol. 2011, 26(2):147-56.

  9. Iizuka S, Kudo Y, Yoshida M, Tsunematsu T, Yoshiko Y, Uchida T, Ogawa I, Miyauchi M, Takata T. Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. Mol Cell Biol. 2011, 31(4):783-92.

  10. Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T. N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. J Oral Pathol Med. 2011, 40(1):77-82.

  11. Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N. RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44-EGFR. Lab Invest. 2011, 91(3):379-91.

  12. Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RY, Yamashita K. SCF(Beta-TrCP) mediates stress-activated MAPK-induced Cdc25B degradation. J Cell Sci. 2011, 15;124(Pt 16):2816-25.

​2010年

  1. Yamada A, Ishimaru N, Arakaki R, Katunuma N, Hayashi Y. Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity. PLoS One. 2010, 5(9):e12894.

  2. Adachi T, Kawakami E, Ishimaru N, Ochiya T, Hayashi Y, Ohuchi H, Tanihara M, Tanaka E, Noji S. Delivery of small interfering RNA with a synthetic collagenpoly(Pro-Hyp-Gly) for gene silencing in vitro and in vivo. Dev Growth Differ. 2010, 52(8):693-9.

  3. Arakaki R, Ishimaru N, Hayashi Y. Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations. Immunotherapy. 2010, 2(3):339-46.

  4. Ishimaru N, Nitta T, Arakaki R, Yamada A, Lipp M, Takahama Y, Hayashi Y. In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy. PLoS One. 2010, 5(1):e8588.

  5. Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity. 2010, 32(1):29-40.

  6. Qi G, Kudo Y, Ando T, Tsunematsu T, Shimizu N, Siriwardena SB, Yoshida M, Keikhaee MR, Ogawa I, Takata T. Nuclear Survivin expression is correlated with malignant behaviors of head and neck cancer together with Aurora-B. Oral Oncol. 2010, 46(4):263-70.

  7. Sakai T, Liu L, Teng X, Ishimaru N, Mukai-Sakai R, Tran NH, Kim SM, Sano N, Hayashi Y, Kaji R, Fukui K. Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice. Int J Cancer. 2010, 126(5):1079-94.

1995-2009年

  1. Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, Mann DJ,Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N,Hara E. Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. J Cell Biol. 2009, 186(3):393-407.

  2. Iwata T, Kuwajima M, Sukeno A, Ishimaru N, Hayashi Y, Wabitsch M, Mizusawa N, Itakura M, Yoshimoto K. YKL-40 secreted from adipose tissue inhibits degradation of type I collagen. Biochem Biophys Res Commun. 2009, 388(3):511-6.

  3. Ishimaru N, Takagi A, Kohashi M, Yamada A, Arakaki R, Kanno J, Hayashi Y. Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance. J Immunol. 2009, 182(10):6576-86.

  4. Arakaki R, Nagaoka A, Ishimaru N, Yamada A, Yoshida S, Hayashi Y. Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy background. Am J Pathol. 2009, 174(5):1715-24.

  5. Hayashi Y, Arakaki R, Ishimaru N. Salivary gland and autoimmunity. J Med Invest. 2009, 56 Suppl:185-91.

  6. Ishimaru N, Arakaki R, Yoshida S, Yamada A, Noji S, Hayashi Y. Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy. J Exp Med. 2008, 205(12):2915-27.

  7. Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J,Akiyama T, Takahama Y. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity. 2008, 29(3):438-50.

  8. Ishimaru N, Yamada A, Kohashi M, Arakaki R, Takahashi T, Izumi K, Hayashi Y. Development of inflammatory bowel disease in Long-Evans Cinnamon rats based on CD4+CD25+Foxp3+ regulatory T cell dysfunction. J Immunol. 2008, 180(10):6997-7008.

  9. Kinouchi N, Ohsawa Y, Ishimaru N, Ohuchi H, Sunada Y, Hayashi Y, Tanimoto Y, Moriyama K, Noji S. Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass. Gene Ther. 2008, 15(15):1126-30.

  10. Kohashi M, Ishimaru N, Arakaki R, Hayashi Y. Effective treatment with oral administration of rebamipide in a mouse model of Sjögren's syndrome. Arthritis Rheum. 2008, 58(2):389-400.

  11. Satomura K, Tokuyama R, Yamasaki Y, Yuasa T, Tatehara S, Ishimaru N, Hayashi Y, Nagayama M. Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa. J Oral Pathol Med. 2007, 36(10):621-4.

  12. Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N,Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N, Hara E. Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals. Proc Natl Acad Sci USA. 2007, 104(38):15034-9.

  13. Izawa T, Ishimaru N, Moriyama K, Kohashi M, Arakaki R, Hayashi Y. Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance. Blood. 2007, 110(1):242-50.

  14. Katunuma N, Le QT, Murata E, Matsui A, Majima E, Ishimaru N, Hayashi Y, Ohashi A. A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by D-galactosamine. FEBS Lett. 2006, 580(15):3699-705.

  15. Suzue N, Nikawa T, Onishi Y, Yamada C, Hirasaka K, Ogawa T, Furochi H, Kosaka H, Ishidoh K, Gu H, Takeda S, Ishimaru N, Hayashi Y, Yamamoto H, Kishi K, Yasui N. Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation. J Bone Miner Res. 2006, 21(5):722-34.

  16. Ishimaru N, Kishimoto H, Hayashi Y, Sprent J. Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol. 2006, 7(7):763-72.

  17. Azuma M, Ashida Y, Tamatani T, Motegi K, Takamaru N, Ishimaru N, Hayashi Y,Sato M. Cepharanthin, a biscoclaurine alkaloid, prevents destruction of acinar tissues in murine Sjögren's syndrome. J Rheumatol. 2006 33(5):912-20.

  18. Ishimaru N, Arakaki R, Omotehara F, Yamada K, Mishima K, Saito I, Hayashi Y. Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands. Mol Cell Biol. 2006, 26(8):2924-35.

  19. Katunuma N, Ohashi A, Sano E, Ishimaru N, Hayashi Y, Murata E. Catechin derivatives: specific inhibitor for caspases-3, 7 and 2, and the prevention of apoptosis at the cell and animal levels. FEBS Lett. 2006, 580(3):741-6.

  20. Miyazaki K, Takeda N, Ishimaru N, Omotehara F, Arakaki R, Hayashi Y. Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome. Am J Pathol. 2005, 167(4):1051-9.

  21. Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi K, Takahashi T, Nomura T, Sakaguchi S, Ueno T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matsushima A, Yamada G, Matsumoto M. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol. 2005, 174(4):1862-70.

  22. Kobayashi M, Yasui N, Ishimaru N, Arakaki R, Hayashi Y. Development of autoimmune arthritis with aging via bystander T cell activation in the mouse model of Sjögren's syndrome. Arthritis Rheum. 2004, 50(12):3974-84.

  23. Ishimaru N, Arakaki R, Katunuma N, Hayashi Y. Critical role of cathepsin-inhibitors for autoantigen processing and autoimmunity. Adv Enzyme Regul. 2004, 44:309-20.

  24. Hayashi Y, Ishimaru N, Arakaki R, Tsukumo S, Fukui H, Kishihara K, Shiota H, Yasutomo K, Hayashi Y. Effective treatment of a mouse model of Sjögren's syndrome with eyedrop administration of anti-CD4 monoclonal antibody. Arthritis Rheum. 2004, 50(9):2903-10.

  25. Hayashi Y, Arakaki R, Ishimaru N. Apoptosis and estrogen deficiency in primary Sjögren syndrome. Curr Opin Rheumatol. 2004, 16(5):522-6.

  26. Endo H, Hirokawa M, Ishimaru N, Tanaka Y, Yamashita M, Sakaki M, Hayashi Y, Sano T. Unique cell membrane expression of topoisomerase-II alpha as a useful diagnostic marker of liposarcoma. Pathol Int. 2004, 54(3):145-50.

  27. Yoneda T, Ishimaru N, Arakaki R, Kobayashi M, Izawa T, Moriyama K, Hayashi Y. Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis. Endocrinology. 2004, 145(5):2384-91.

  28. Arakaki R, Ishimaru N, Saito I, Kobayashi M, Yasui N, Sumida T, Hayashi Y. Development of autoimmune exocrinopathy resembling Sjögren's syndrome in adoptively transferred mice with autoreactive CD4+ T cells. Arthritis Rheum. 2003, 48(12):3603-9.

  29. Ogawa K, Nagahiro S, Arakaki R, Ishimaru N, Kobayashi M, Hayashi Y. Anti-alpha-fodrin autoantibodies in Moyamoya disease. Stroke. 2003, 34(12):e244-6.

  30. Ishimaru N, Arakaki R, Watanabe M, Kobayashi M, Miyazaki K, Hayashi Y. Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background. Am J Pathol. 2003, 163(4):1481-90.

  31. Hayashi Y, Arakaki R, Ishimaru N. The role of caspase cascade on the development of primary Sjögren's syndrome. J Med Invest. 2003, 50(1-2):32-8.

  32. Saegusa K, Ishimaru N, Yanagi K, Arakaki R, Ogawa K, Saito I, Katunuma N, Hayashi Y. Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. J Clin Invest. 2002, 110(3):361-9.

  33. Saegusa K, Ishimaru N, Yanagi K, Mishima K, Arakaki R, Suda T, Saito I, Hayashi Y. Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjögren's syndrome. J Immunol. 2002, 169(2):1050-7.

  34. Ishimaru N, Yanagi K, Ogawa K, Suda T, Saito I, Hayashi Y. Possible role of organ-specific autoantigen for Fas ligand-mediated activation-induced cell death in murine Sjögren's syndrome. J Immunol. 2001, 167(10):6031-7.

  35. Saegusa K, Ishimaru N, Haneji N, Yanagi K, Yoneda T, Saito I, Hayashi Y. Mechanisms of neonatal tolerance induced in an animal model for primary Sjögren's syndrome by intravenous administration of autoantigen. Scand J Immunol. 2000, 52(3):264-70.

  36. Saegusa K, Ishimaru N, Yanagi K, Haneji N, Nishino M, Azuma M, Saito I, Hayashi Y. Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjögren's syndrome. J Immunol. 2000, 165(4):2251-7.

  37. Aota K, Azuma M, Yamashita T, Tamatani T, Motegi K, Ishimaru N, Hayashi Y, Sato M. 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Biochem Biophys Res Commun. 2000, 273(3):1168-74.

  38. Ishimaru N, Yoneda T, Saegusa K, Yanagi K, Haneji N, Moriyama K, Saito I, Hayashi Y. Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis. Am J Pathol. 2000, 156(5):1557-64.

  39. Saegusa K, Ishimaru N, Yanagi K, Haneji N, Nishino M, Azuma M, Saito I, Hayashi Y. Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjögren's syndrome (SS) through up-regulated Th2 response. Clin Exp Immunol. 2000, 119(2):354-60.

  40. Ishimaru N, Saegusa K, Yanagi K, Haneji N, Saito I, Hayashi Y. Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through fas-mediated apoptosis. Am J Pathol. 1999, 155(1):173-81.

  41. Takahashi M, Ishimaru N, Yanagi K, Saegusa K, Haneji N, Shiota H, Hayashi Y. Requirement for splenic CD4+ T cells in the immune privilege of the anterior chamber of the eye. Clin Exp Immunol. 1999, 116(2):231-7.

  42. Saito I, Haruta K, Shimuta M, Inoue H, Sakurai H, Yamada K, Ishimaru N, Higashiyama H, Sumida T, Ishida H, Suda T, Noda T, Hayashi Y, Tsubota K. Fas ligand-mediated exocrinopathy resembling Sjögren's syndrome in mice transgenic for IL-10. J Immunol. 1999, 162(5):2488-94.

  43. Yanagi K, Ishimaru N, Haneji N, Saegusa K, Saito I, Hayashi Y. Anti-120-kDa alpha-fodrin immune response with Th1-cytokine profile in the NOD mouse model of Sjögren's syndrome. Eur J Immunol. 1998, 28(10):3336-45.

  44. Tsubota K, Saito I, Ishimaru N, Hayashi Y. Use of topical cyclosporin A in a primary Sjögren's syndrome mouse model. Invest Ophthalmol Vis Sci. 1998, 39(9):1551-9.

  45. Yanagi K, Haneji N, Ishimaru N, Saito I, Hayashi Y. Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. Clin Exp Immunol. 1997, 110(3):440-6.

  46. Takahashi M, Ishimaru N, Yanagi K, Haneji N, Saito I, Hayashi Y. High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. Clin Exp Immunol. 1997, 109(3):555-61.

  47. Ishimaru N, Haneji N, Hamano H, Kumiko Y, Takahashi M, Hayashi Y. Accelerated onset of age-related autoimmune lesions in MRL/+ mice by ovariectomy. Mech Ageing Dev. 1997, 93(1-3):145-56.

  48. Hayashi Y, Haneji N, Hamano H, Yanagi K, Takahashi M, Ishimaru N. Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjögren's syndrome. Cell Immunol. 1996, 171(2):217-25.

  49. Hamano H, Haneji N, Yanagi K, Ishimaru N, Hayashi Y. Expression of HLA-DR and cytokine genes on interferon-gamma-stimulated human salivary gland cell line. Pathobiology. 1996, 64(5):255-61.

  50. Yanagi K, Haneji N, Ishimaru N, Hamano H, Hayashi Y. Immunopathological analysis of mucosal melanocyte distribution in the human lower lip of the elderly. Pathobiology. 1996, 64(3):156-60.

  51. Hayashi Y, Hamano H, Haneji N, Ishimaru N, Yanagi K. Biased T cell receptor Vbeta gene usage during specific stages of the development of autoimmune sialadenitis in the MRL/lpr mouse model of Sjögren's syndrome. Arthritis Rheum. 1995, 38(8):1077-84.

和文総説・症例報告および著書

  1. 石丸直澄 シェーグレン症候群疾患モデルからのトランスレーショナル研究　炎症と免疫31(3）35-39, 2023

  2. 石丸直澄 臓器間ネットワークと自己免疫疾患　臨床免疫・アレルギー科　80（3）1-6, 2023

  3. 大塚邦紘、常松貴明、石丸直澄　シェーグレン症候群の病理診断　診断病理39（4）, 2022

  4. 大塚邦紘、常松貴明、牛尾綾、佐藤真美、石丸直澄　カラー図説：シェーグレン症候群の病理　日本臨床80（10）, 2022

  5. 石丸直澄 難病研究の進歩　シェーグレン症候群　生体の科学　71（5）：476-747, 2020

  6. 大塚邦紘、石丸直澄  シェーグレン症候群における濾胞ヘルパーT細胞の役割　臨床免疫・アレルギー科　73（3）：241-248, 2020

  7. 牛尾綾、大塚邦紘、新垣理恵子、工藤保誠、石丸直澄　CCL22と自己免疫疾患　臨床免疫・アレルギー科　71（5）：1-7, 2019

  8. 石丸直澄、山田安希子　シェーグレン症候群の病態機序と制御性T細胞　医学のあゆみ　268（13）：1241-1245, 2019

  9. 牛尾綾、大塚邦紘、新垣理恵子、工藤保誠、石丸直澄　シェーグレン症候群研究の最前線　細胞　50(10):528-531, 2018

  10. 石丸直澄、林良夫　口唇腺生検病理診断　シェーグレン症候群の診断と治療マニュアル（改訂版第3版）70-75, 2018

  11. 石丸直澄 　膠原病の病理　唾液腺病変　病理と臨床 36(6): 580-585, 2018

  12. 石丸直澄 口腔免疫とその異常 CLINICAL CALCIUM 27(10):21-26, 2017

  13. Yoshio Hayashi, Naozumi Ishimaru Autoimmunity: Aging Mous Model for Autoimmune Diseases Handbook of Immunosenescence 1-11, 2017

  14. 石丸直澄　環境因子と免疫トレランスの破綻　臨床免疫・アレルギー科　67：360-365, 2017

  15. 石丸直澄　ナノマテリアルと免疫システム〜カーボンナノチューブに対する免疫反応と炎症病態〜　医学のあゆみ　 259（3）：241-246,　2016

  16. 石丸直澄（分担）　わかりやすい病理学　2016

  17. 長谷川智一, 赤澤友基, 永井宏和, 北村尚正, 石丸直澄, 上田(山口)公子, 中川弘, 郡由紀子, 山本愛美, 岩本勉　幼児期の小児の口蓋に発生した血管腫の1例小児歯科学雑誌 53（3）：448-453,2014.

  18. 石丸直澄　口腔病理から見たドライマウスの病態と最新研究　日本歯科医師会雑誌　67(2):21-30,2014.

  19. 林良夫、石丸直澄　口唇腺生検病理診断　シェーグレン症候群の診断と治療マニュアル（改訂第2版）79-85,2014.

  20. 青田桂子, 山村佳子, 可児耕一, 高野栄之, 茂木勝美, 桃田幸弘, 石丸直澄, 東雅之 　Sjogren症候群患者の唾液腺腺房構造破壊阻止 : セファランチンの有効性に関する臨床病理学的研究, 　日本口腔科学会雑誌 62（4）：254-261頁, 2013.

  21. 髙丸菜都美, 内田大亮, 大江剛, 永井宏和, 石丸直澄, 宮本洋二 下顎小臼歯部に発生した骨形成を伴う巨細胞エプーリスの1例　日本口腔外科学会雑誌 58（11）： 651-654, 2012.

  22. 林良夫、新垣理恵子、石丸直澄　Sjögren症候群　日本内科学会雑誌　5:1262-1268, 2011.

  23. 石丸直澄、井澤俊、林良夫　RANKLとFasによる免疫応答の制御　臨床免疫・アレルギー科　55:142-147, 2011.

  24. 石丸直澄, 小橋真之 , 山田 安希子, 新垣 理恵子, 林 良夫　新生児におけるダイオキシンへの曝露と自己免疫病の発生 　臨床免疫・アレルギー科 53:92-96, 2010.

  25. 舘原誠晃, 藤澤健司, 永井宏和, 重本修伺, 大倉一夫, 石丸直澄, 林良夫, 宮本洋二 　切除からインプラントを維持源としたエピテーゼまで一貫治療を行った上顎洞悪性線維性組織球腫の1例　四国歯学会雑誌 22（2）：179-183, 2010.

  26. 波多野 寛子, 重石 秀生, 工藤 保誠, 東川 晃一郎, 飛梅 圭, 高田 隆, 鎌田 伸之 : 骨形成線維腫の病態解明への基礎研究, 組織培養研究, 30(2-4) :135-143, 2012.

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